Pertussis immunity and epidemiology: mode and duration of vaccine-induced immunity.

ABSTRACT: The resurgence of pertussis in some countries that maintain high vaccination coverage has drawn attention to gaps in our understanding of the epidemiological effects of pertussis vaccines. In particular, major questions surround the nature, degree and durability of vaccine protection. To address these questions, we used mechanistic transmission models to examine regional time series incidence data from Italy in the period immediately following the introduction of acellular pertussis (aP) vaccine. Our results concur with recent animal-challenge experiments wherein infections in aP-vaccinated individuals proved as transmissible as those in naive individuals but much less symptomatic. On the other hand, the data provide evidence for vaccine-driven reduction in susceptibility, which we quantif

SUBMITTER: Magpantay FMG 

PROVIDER: S-EPMC4792787 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature