Formulation development and evaluation of medicated chewing gum of anti-emetic drug.

ABSTRACT:

Context

Medicated chewing gum (MCG) of Domperidone Maleate (DM) was developed by direct compression method with the goal to achieve quick onset of action and to improve patient compliance.

Objective

Formulation development of MCG of DM and optimization of the formulation by screening of different excipients.

Material and methods

MCG containing DM was prepared by screening different concentrations of sweeteners, flavouring agents, softening agents, lubricants and anti-adherents by changing one variable at a time. Performance evaluation was carried out by evaluating size, shape, thickness, taste, scanning electron microscopy, texture analysis, in vivo drug release study, ex vivo buccal permeation study and by studying statistical analysis for quality.

Results and dis

SUBMITTER: Paradkar M 

PROVIDER: S-EPMC4792901 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature