Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis.

ABSTRACT: Cognitive control, a set of functions that develop throughout adolescence, is important in the pathogenesis of psychotic disorders. Whether cognitive control has a role in conferring vulnerability for the development of psychotic illness is still unknown. The aim of this study was to investigate the neural systems supporting cognitive control in individuals deemed to be potentially prodromal for psychotic illness. We recruited 56 participants at clinical high-risk (CHR) for psychosis based on the Structured Interview for Psychosis-Risk Syndromes (SIPS) and 49 healthy controls. Twelve of the CHR participants eventually developed psychosis. We compared functional magnetic resonance imaging (fMRI) BOLD signal during the performance of the Simon task. We tested for differences between CHR indi

SUBMITTER: Colibazzi T 

PROVIDER: S-EPMC4793108 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature