Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit.

ABSTRACT: Fluctuations in neural activity can produce states that facilitate and accelerate task-related performance. Acquisition of trace eyeblink conditioning (tEBC) in the rabbit is enhanced when trials are contingent on optimal pretrial activity in the hippocampus. Other regions which are essential for whisker-signaled tEBC, such as the cerebellar interpositus nucleus (IPN), somatosensory and prelimbic cortices, may also show optimal connectivity prior to successful performance. Functional magnetic resonance imaging (fMRI) was acquired in nine rabbits during tEBC on the first and tenth days of initial training and once again after a 30-d, training-free hiatus. Data acquired during the intertrial interval was parsed depending on whether or not a conditioned response (CR) occurred on the upcoming

SUBMITTER: Schroeder MP 

PROVIDER: S-EPMC4793201 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature