The effect of ribosomal protein S15a in lung adenocarcinoma.

ABSTRACT:

Background

RPS15A (Ribosomal Protein S15A) promotes mRNA/ribosome interactions in translation. It is critical for the process of eukaryotic protein biosynthesis. Recently, aberrantly expressed RPS15A was found in the hepatitis virus and in malignant tumors. However, the role of RPS15A has not been fully revealed on the development of lung cancer.

Method

In this study, a Tissue Microarray (TMA) of primary lung adenocarcinoma tissue specimens was carried out. Furthermore, to further investigate the function of RPS15A in lung cancer, RPS15A-specific short hairpin RNA (shRNA) expressing lentivirus (Lv-shRPS15A) was constructed and used to infect H1299 and A549 cells.

Result

Our data showed that RPS15A expression was increased in tumor tissues. Furthermore, the knockdown o

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4793315 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature