Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses.

ABSTRACT:

Objective

Insulin-like growth factor-1 (IGF1) regulates differentiation and growth of tissues and reduces stress and injury. IGF1 also in a tissue-specific manner modulates the differentiation and lipid storage capacity of adipocytes in vitro, but its roles in adipose tissue development and response to stress are not known.

Methods

To study IGF1 in vivo, the cellular sources of adipose tissue Igf1 expression were identified and mice were generated with targeted deletion in adipocytes and macrophages. The effects of adipocyte and macrophage deficiency of IGF1 on adipose tissue development and the response to chronic (high-fat feeding) and acute (cold challenge) stress were studied.

Results

The expression of Igf1 by adipose tissue was derived from multiple cell types in

SUBMITTER: Chang HR 

PROVIDER: S-EPMC4793714 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature