Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort.

ABSTRACT:

Objectives

To characterize the prevalence of cognitive and behavioral symptoms using a cognitive/behavioral screening battery in a large prospective multicenter study of amyotrophic lateral sclerosis (ALS).

Methods

Two hundred seventy-four patients with ALS completed 2 validated cognitive screening tests and 2 validated behavioral interviews with accompanying caregivers. We examined the associations between cognitive and behavioral performance, demographic and clinical data, and C9orf72 mutation data.

Results

Based on the ALS Cognitive Behavioral Screen cognitive score, 6.5% of the sample scored below the cutoff score for frontotemporal lobar dementia, 54.2% scored in a range consistent with ALS with mild cognitive impairment, and 39.2% scored in the normal range. The

SUBMITTER: Murphy J 

PROVIDER: S-EPMC4793785 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature