Movement based artifacts may contaminate extracellular electrical recordings from GI muscles.

ABSTRACT:

Background

Electrical slow waves drive peristaltic contractions in the stomach and facilitate gastric emptying. In gastroparesis and other disorders associated with altered gastric emptying, motility defects have been related to altered slow wave frequency and disordered propagation. Experimental and clinical measurements of slow waves are made with extracellular or abdominal surface recording.

Methods

We tested the consequences of muscle contractions and movement on biopotentials recorded from murine gastric muscles with array electrodes and pairs of silver electrodes.

Key results

Propagating biopotentials were readily recorded from gastric sheets composed of the entire murine stomach. The biopotentials were completely blocked by nifedipine (2 μmol L(-1) ) that block

SUBMITTER: Bayguinov O 

PROVIDER: S-EPMC4793914 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature