Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations.

ABSTRACT: The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in an extended and more effective manner, while opening opportunities for many more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are de

SUBMITTER: Chen TC 

PROVIDER: S-EPMC4793926 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature