Developing Repair Materials for Stress Urinary Incontinence to Withstand Dynamic Distension.

ABSTRACT:

Background

Polypropylene mesh used as a mid-urethral sling is associated with severe clinical complications in a significant minority of patients. Current in vitro mechanical testing shows that polypropylene responds inadequately to mechanical distension and is also poor at supporting cell proliferation.

Aims and objectives

Our objective therefore is to produce materials with more appropriate mechanical properties for use as a sling material but which can also support cell integration.

Methods

Scaffolds of two polyurethanes (PU), poly-L-lactic acid (PLA) and co-polymers of the two were produced by electrospinning. Mechanical properties of materials were assessed and compared to polypropylene. The interaction of adipose derived stem cells (ADSC) with the scaffolds was

SUBMITTER: Hillary CJ 

PROVIDER: S-EPMC4794140 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature