A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia.

ABSTRACT:

Importance

Recent data suggest that treatment with antipsychotics is associated with reductions in cortical gray matter in patients with schizophrenia. These findings have led to concerns about the effect of antipsychotic treatment on brain structure and function; however, no studies to date have measured cortical function directly in individuals with schizophrenia and shown antipsychotic-related reductions of gray matter.

Objective

To examine the effects of antipsychotics on brain structure and function in patients with first-episode schizophrenia, using cortical thickness measurements and administration of the AX version of the Continuous Performance Task (AX-CPT) during event-related functional magnetic resonance imaging.

Design, setting, and participants

This case

SUBMITTER: Lesh TA 

PROVIDER: S-EPMC4794273 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature