Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.

ABSTRACT:

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Despite advances in treatment approaches for head and neck squamous cell carcinoma (HNSCC), survival rates have remained stagnant due to the paucity of preclinical models that accurately reflect the human tumor. Patient-derived xenografts (PDX) are an emerging model system where patient tumors are implanted directly into mice. Increased understanding of the application and limitations of PDXs will facilitate their rational use. Studies to date have not reported protein profiles of PDXs. Therefore, we developed a large cohort of HNSCC PDXs and found that tumor take rate was not influenced by the clinical, pathologic, or processing features. Protein expression profiles, from a subset of the PDXs, were characterized by reverse-phase protein array and the data was compared w

SUBMITTER: Li H 

PROVIDER: S-EPMC4794346 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature