ERRα Is a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer.

ABSTRACT:

Purpose

Estrogen-related receptor alpha (ERRα) signaling has recently been implicated in breast cancer. We investigated the clinical value of ERRα in randomized cohorts of tamoxifen-treated and adjuvant-untreated patients.

Experimental design

Cox proportional hazards regression was used to evaluate the significance of associations between ERRα gene expression levels and patient DMFS in a previously published microarray dataset representing 2,000 breast tumor cases derived from multiple medical centers worldwide. The 912 tumors used for immunostaining were from a tamoxifen-randomized primary breast cancer trial conducted in Stockholm, Sweden, during 1976-1990. Mouse model was used to study the effect of tamoxifen treatment on lung colonization of MDA-MB-231 control cells and

SUBMITTER: Manna S 

PROVIDER: S-EPMC4794381 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature