Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.

ABSTRACT: Risks of tumor recurrence after surgical resection have been known for decades, but the mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line responders after surgical stress, may play an important role in linking inflammation to cancer progression. In response to stress, neutrophils can expel their protein-studded chromatin to form local snares known as neutrophil extracellular traps (NET). In this study, we asked whether, as a result of its ability to ensnare moving cells, NET formation might promote metastasis after surgical stress. Consistent with this hypothesis, in a cohort of patients undergoing attempted curative liver resection for metastatic colorectal cancer, we observed that increased postoperative NET formation was associated with a >4-fold

SUBMITTER: Tohme S 

PROVIDER: S-EPMC4794393 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature