TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression.

ABSTRACT: In metastatic breast cancer, the acquisition of malignant traits has been associated with the increased rate of cell growth and division, mobility, resistance to chemotherapy, and invasiveness. While screening for the key regulators of cancer metastasis, we observed that neurotrophin receptor TrkB is frequently overexpressed in breast cancer patients and breast cancer cell lines. Additionally, we demonstrate that TrkB expression and clinical breast tumor pathological phenotypes show significant correlation. Moreover, TrkB expression was significantly upregulated in basal-like, claudin-low, and metaplastic breast cancers from a published microarray database and in patients with triple-negative breast cancer, which is associated with a higher risk of invasive recurrence. Interestingly, we id

SUBMITTER: Kim MS 

PROVIDER: S-EPMC4794608 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature