GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer.

ABSTRACT:

Background

A large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer. We have studied the DNA methylation status of 27 500 gene promoter regions in 24 gastric adenocarcinomas from a Norwegian cohort, and aimed at identifying the hypermethylated regions. We have compared our findings to the gene expression in the same tissue, and linked our results to prognosis and survival.

Methods

Biopsies from gastric adenocarcinomas and adjacent normal gastric mucosa were obtained from 24 patients following surgical resection of the tumor. Genome-wide DNA methylation profiling of the tumor and matched non-cancerous mucosa was performed. The results were compared to whole transcriptome cDNA microarray analysis of the same material.

Result

SUBMITTER: Eftang LL 

PROVIDER: S-EPMC4794813 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature