Runs of homozygosity and inbreeding in thyroid cancer.

ABSTRACT:

Background

Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs function in a co-dominant manner, and studies have not found evidence for recessively functioning disease loci in TC. Our study examines whether homozygosity is associated with an increased risk of TC and searches for novel recessively acting disease loci.

Methods

Data from a previously conducted GWAS were used for the estimation of the proportion of phenotypic variance explained by all common SNPs, the detection of runs of homozygosity (ROH) and the determination of inbreeding to unravel their influence on TC.

Results

Inbreeding coefficients were signifi

SUBMITTER: Thomsen H 

PROVIDER: S-EPMC4794977 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature