Expression analysis in intestinal mucosa reveals complex relations among genes under the association peaks in celiac disease.

ABSTRACT: Celiac disease is a chronic immune-mediated disorder with an important genetic component. To date, there are 57 independent association signals from 39 non-HLA loci, and a total of 66 candidate genes have been proposed. We aimed to scrutinize the functional implication of 45 of those genes by analyzing their expression in the disease tissue of celiac patients (at diagnosis/treatment) compared with non-celiac controls. Moreover, we investigated the SNP genotype effect in gene expression and performed coexpression analyses. Several genes showed differential expression among disease groups, most of them related to immune response. Multiple trans-eQTLs but only four cis-eQTLs were found, and surprisingly the genotype effect seems to be stimulus dependent as it differs among groups. Coexpressio

SUBMITTER: Plaza-Izurieta L 

PROVIDER: S-EPMC4795102 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature