Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.

ABSTRACT: Wine is the most popular alcoholic beverage around the world and because of its importance in society has been widely studied. Understanding what drives its flavor has been a quest for decades but much is still unknown and will be determined at least in part by individual taste preferences. Recently studies in the genetics of taste have uncovered the role of different genes in the determination of food preferences giving new insight on its physiology. In this context we have performed a genome-wide association study on red and white wine liking using three isolated populations collected in Italy, and replicated our results on two additional populations coming from the Netherland and Central Asia for a total of 3885 samples. We have found a significant association (P=2.1 × 10(-8)) between w

SUBMITTER: Pirastu N 

PROVIDER: S-EPMC4795214 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature