Respiratory Variability during Sleep in Methadone Maintenance Treatment Patients.

ABSTRACT:

Study objectives

Methadone maintenance treatment (MMT) patients have a high prevalence of central sleep apnea and ataxic breathing related to damage to central respiratory rhythm control. However, the quantification of sleep apnea indices requires laborious manual scoring, and ataxic breathing pattern is subjectively judged by visual pattern recognition. This study proposes a semi-automated technique to characterize respiratory variability in MMT patients.

Methods

Polysomnography, blood, and functional outcomes of sleep questionnaire (FOSQ) from 50 MMT patients and 20 healthy subjects with matched age, sex, and body mass index, were analyzed. Inter-breath intervals (IBI) were extracted from the nasal cannula pressure signal. Variability of IBI over 100 breaths was quantified

SUBMITTER: Nguyen CD 

PROVIDER: S-EPMC4795289 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature