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Alteration of interferon-?/? receptors in chronic hepatitis B patients.

ABSTRACT: The present study determined type I interferon (IFN) receptor (interferon-?/? receptor (IFNAR)) and its predicable role in interferon-?2b treatment in chronic hepatitis B (CHB) patients.Expression of IFN-?/?R-1 and IFN-?/?R-2 in peripheral blood mononuclear cells and in liver tissue was measured by flow cytometry, immunofluorescence, immunohistochemistry and RT-PCR.IFN-?/?R-1 and IFN-?/?R-2 in monocytes and lymphocytes increased in CHB patients. Expression of IFNAR-1 and IFNAR-2 in liver had positive correlation with HBV-DNA in liver tissue. Expression of IFN-?/?R in lymphocytes and monocytes increased in the first month, but then decreased during the subsequent interferon-?2b treatment, patients who had higher levels of IFN-?/?R-2 in monocytes prior to therapy showed better viral response than those with lower levels.Expression of IFN-?/?R-2 in monocytes can be used as a predictable parameter to evaluate the effect of IFN-? treatment in CHB patients.

SUBMITTER: Meng F 

PROVIDER: S-EPMC4795458 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Alteration of interferon-α/β receptors in chronic hepatitis B patients.

Meng Fanli F   Wang Jiefei J   Ge Jian J   Fan Xiaopeng X   Wang Bing B   Han Liyan L   Kisseleva Tatiana T   Paik YongHan Y   Brenner David A DA   Wang Kai K  

Journal of clinical immunology 20110329 3

<h4>Background</h4>The present study determined type I interferon (IFN) receptor (interferon-α/β receptor (IFNAR)) and its predicable role in interferon-α2b treatment in chronic hepatitis B (CHB) patients.<h4>Methods</h4>Expression of IFN-α/βR-1 and IFN-α/βR-2 in peripheral blood mononuclear cells and in liver tissue was measured by flow cytometry, immunofluorescence, immunohistochemistry and RT-PCR.<h4>Results</h4>IFN-α/βR-1 and IFN-α/βR-2 in monocytes and lymphocytes increased in CHB patients.  ...[more]

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