Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD.

ABSTRACT:

Background

It is well known in Huntington's disease that cytosine-adenine-guanine expansion and age at study entry are predictive of the timing of motor diagnosis. The goal of this study was to assess whether additional motor, imaging, cognitive, functional, psychiatric, and demographic variables measured at study entry increased the ability to predict the risk of motor diagnosis over 12 years.

Methods

One thousand seventy-eight Huntington's disease gene-expanded carriers (64% female) from the Neurobiological Predictors of Huntington's Disease study were followed up for up to 12 y (mean = 5, standard deviation = 3.3) covering 2002 to 2014. No one had a motor diagnosis at study entry, but 225 (21%) carriers prospectively received a motor diagnosis. Analysis was performed with

SUBMITTER: Long JD 

PROVIDER: S-EPMC4795466 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature