In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis.

ABSTRACT: Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect against disease. Recent findings suggest that favourable outcomes following Mycobacterium tuberculosis infection arise from finely balanced inflammatory and regulatory pathways, achieving pathogen control without immunopathology. We hypothesised that HIV-1 and antiretroviral therapy (ART) exert widespread changes to cell mediated immunity, which may compromise the optimal host protective response to TB and provide novel insights into the correlates of immune protection and pathogenesis. We sought to define these effects in patients with active TB

SUBMITTER: Bell LC 

PROVIDER: S-EPMC4795555 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature