No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population.

ABSTRACT:

Aim

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, and it promotes the development and function of dopaminergic and serotonergic neurons. The Met allele of the BDNF Val66Met polymorphism is associated with a decrease in activity-dependent secretion of BDNF compared with the Val allele, and a number of studies have provided evidence for the association between this polymorphism and obsessive-compulsive disorder (OCD). The purpose of this study was to investigate whether this functional variant of the BDNF gene is associated with OCD and treatment response in patients with OCD in the Japanese population.

Methods

We first performed a case-control association study between the BDNF Val66Met polymorphism and OCD (175 cases and 2,027 controls). Th

SUBMITTER: Umehara H 

PROVIDER: S-EPMC4795591 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature