Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men.

ABSTRACT:

Objective

A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality.

Methods

Men participating in population based health screenings during 1981-1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional haz

SUBMITTER: Meyer HE 

PROVIDER: S-EPMC4795600 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature