CatRAPID signature: identification of ribonucleoproteins and RNA-binding regions.

ABSTRACT:

Motivation

Recent technological advances revealed that an unexpected large number of proteins interact with transcripts even if the RNA-binding domains are not annotated. We introduce catRAPID signature to identify ribonucleoproteins based on physico-chemical features instead of sequence similarity searches. The algorithm, trained on human proteins and tested on model organisms, calculates the overall RNA-binding propensity followed by the prediction of RNA-binding regions. catRAPID signature outperforms other algorithms in the identification of RNA-binding proteins and detection of non-classical RNA-binding regions. Results are visualized on a webpage and can be downloaded or forwarded to catRAPID omics for predictions of RNA targets.

Availability and implementation

catRAPI

SUBMITTER: Livi CM 

PROVIDER: S-EPMC4795616 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature