TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells.

ABSTRACT:

Background

Childhood acute lymphoblastic leukaemia (ALL) is the most common malignancy in children. Despite high cure rates, side effects and late consequences of the intensive treatments are common. Unquestionably, the identification of new therapeutic targets will lead to safer, more effective treatments. We identified TES promoter methylation and transcriptional silencing as a very common molecular abnormality in childhood ALL, irrespective of molecular subtype. The aims of the present study were to demonstrate that TES promoter methylation is aberrant, to determine the effects of TES re-expression in ALL, and to determine if those effects are mediated via TP53 activity.

Methods

Normal fetal and adult tissue DNA was isolated and TES promoter methylation determined by Sequ

SUBMITTER: Weeks RJ 

PROVIDER: S-EPMC4795691 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature