HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants.

ABSTRACT: Compaction of DNA into chromatin is a characteristic feature of eukaryotic organisms. The core (H2A, H2B, H3, H4) and linker (H1) histone proteins are responsible for this compaction through the formation of nucleosomes and higher order chromatin aggregates. Moreover, histones are intricately involved in chromatin functioning and provide a means for genome dynamic regulation through specific histone variants and histone post-translational modifications. 'HistoneDB 2.0--with variants' is a comprehensive database of histone protein sequences, classified by histone types and variants. All entries in the database are supplemented by rich sequence and structural annotations with many interactive tools to explore and compare sequences of different variants from various organisms. The core of the

SUBMITTER: Draizen EJ 

PROVIDER: S-EPMC4795928 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature