DbWGFP: a database and web server of human whole-genome single nucleotide variants and their functional predictions.

ABSTRACT: The recent advancement of the next generation sequencing technology has enabled the fast and low-cost detection of all genetic variants spreading across the entire human genome, making the application of whole-genome sequencing a tendency in the study of disease-causing genetic variants. Nevertheless, there still lacks a repository that collects predictions of functionally damaging effects of human genetic variants, though it has been well recognized that such predictions play a central role in the analysis of whole-genome sequencing data. To fill this gap, we developed a database named dbWGFP (a database and web server of human whole-genome single nucleotide variants and their functional predictions) that contains functional predictions and annotations of nearly 8.58 billion possible huma

SUBMITTER: Wu J 

PROVIDER: S-EPMC4795934 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature