Tissue-of-origin-specific gene repositioning in breast and prostate cancer.

ABSTRACT: Genes have preferential non-random spatial positions within the cell nucleus. The nuclear position of a subset of genes differ between cell types and some genes undergo repositioning events in disease, including cancer. It is currently unclear whether the propensity of a gene to reposition reflects an intrinsic property of the locus or the tissue. Using quantitative FISH analysis of a set of genes which reposition in cancer, we test here the tissue specificity of gene repositioning in normal and malignant breast or prostate tissues. We find tissue-specific organization of the genome in normal breast and prostate with 40 % of genes occupying differential positions between the two tissue types. While we demonstrate limited overlap between gene sets that repositioned in breast and prostate ca

SUBMITTER: Meaburn KJ 

PROVIDER: S-EPMC4795970 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature