Tourniquet Use During Knee Replacement Surgery May Contribute to Muscle Atrophy in Older Adults.

ABSTRACT: Muscle atrophy after total knee arthroplasty (TKA) occurs at a rate of 1% per day for the first 2 wk. Our hypothesis is that tourniquet-induced ischemia-reperfusion injury occurring during TKA influences metabolism and may contribute to atrophy. Identifying pathways that are upregulated during this critical "14-d window" after surgery may help us delineate therapeutic approaches to avoid muscle loss.

SUBMITTER: Dreyer HC 

PROVIDER: S-EPMC4795986 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature