Reconstruction of the Regulatory Network for Bacillus subtilis and Reconciliation with Gene Expression Data.

ABSTRACT: We introduce a manually constructed and curated regulatory network model that describes the current state of knowledge of transcriptional regulation of Bacillus subtilis. The model corresponds to an updated and enlarged version of the regulatory model of central metabolism originally proposed in 2008. We extended the original network to the whole genome by integration of information from DBTBS, a compendium of regulatory data that includes promoters, transcription factors (TFs), binding sites, motifs, and regulated operons. Additionally, we consolidated our network with all the information on regulation included in the SporeWeb and Subtiwiki community-curated resources on B. subtilis. Finally, we reconciled our network with data from RegPrecise, which recently released their own less compr

SUBMITTER: Faria JP 

PROVIDER: S-EPMC4796004 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature