Using Incomplete Trios to Boost Confidence in Family Based Association Studies.

ABSTRACT: Most currently available family based association tests are designed to account only for nuclear families with complete genotypes for parents as well as offspring. Due to the availability of increasingly less expensive generation of whole genome sequencing information, genetic studies are able to collect data for more families and from large family cohorts with the goal of improving statistical power. However, due to missing genotypes, many families are not included in the family based association tests, negating the benefits of large scale sequencing data. Here, we present the CIFBAT method to use incomplete families in Family Based Association Test (FBAT) to evaluate robustness against missing data. CIFBAT uses quantile intervals of the FBAT statistic by randomly choosing valid completio

SUBMITTER: Dhankani V 

PROVIDER: S-EPMC4796035 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature