Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG.

ABSTRACT:

Objectives

Despite over a century of research and the careful scrutiny of many promising targets, there is currently no vaccine available for the prevention of Streptococcus pyogenes infection. Through analysis of the protective, anti-streptococcal components of pooled human immunoglobulin, we previously identified ten highly conserved and invariant S. pyogenes antigens that contribute to anti-streptococcal immunity in the adult population. We sought to emulate population immunity to S. pyogenes through a process of active vaccination, using the antigens targeted by pooled human immunoglobulin.

Methods

Seven targets were produced recombinantly and mixed to form a multicomponent vaccine (Spy7). Vaccinated mice were challenged with S. pyogenes isolates representing four global

SUBMITTER: Reglinski M 

PROVIDER: S-EPMC4796040 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature