NELL-1 expression in tumors of cartilage.

ABSTRACT:

Background/aims

NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.

Methods

Immunohistochemical expression was examined in human pathologic specimens.

Results

Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.

Conclusion

In summary, NELL-1 demonstrates reliable and consistent expression acro

SUBMITTER: Shen J 

PROVIDER: S-EPMC4796526 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature