Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children.

ABSTRACT: The colonization pattern of intestinal microbiota during childhood may impact health later in life, but children older than 1 year are poorly studied. We followed healthy children aged 1-4 years (n=28) for up to 12 months, during which a synbiotic intervention and occasional antibiotics intake occurred, and compared them with adults from the same region. Microbiota was quantified with the HITChip phylogenetic microarray and analyzed with linear mixed effects model and other statistical approaches. Synbiotic administration increased the stability of Actinobacteria and antibiotics decreased Clostridium cluster XIVa abundance. Bacterial diversity did not increase in 1- to 5-year-old children and remained significantly lower than in adults. Actinobacteria, Bacilli and Clostridium cluster IV re

SUBMITTER: Cheng J 

PROVIDER: S-EPMC4796939 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature