Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses.

ABSTRACT:

Background

Tumor necrosis factor/tumor necrosis factor receptor superfamily members conform a group of molecular interaction pathways of essential relevance during the process of T-cell activation and differentiation toward effector cells and particularly for the maintenance phase of the immune response. Specific blockade of these interacting pathways, such as CD40-CD40L, contributes to modulate the deleterious outcome of allogeneic immune responses. We postulated that antagonizing the interaction of LIGHT expression on activated T cells with its receptors, herpesvirus entry mediator and lymphotoxin β receptor, may decrease T cell-mediated allogeneic responses.

Methods

A flow cytometry competition assay was designed to identify anti-LIGHT monoclonal antibodies capable to pre

SUBMITTER: del Rio ML 

PROVIDER: S-EPMC4796945 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature