Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.

ABSTRACT:

Background

There is an established association between type 2 diabetes and accelerated cognitive decline. The exact mechanism linking type 2 diabetes and reduced cognitive function is less clear. The monoamine system, which is extensively involved in cognition, can be altered by type 2 diabetes status. Thus, this study hypothesized that sequence variants in genes linked to dopamine metabolism and associated pathways are associated with cognitive function as assessed by the Digit Symbol Substitution Task, the Modified Mini-Mental State Examination, the Stroop Task, the Rey Auditory-Verbal Learning Task, and the Controlled Oral Word Association Task for Phonemic and Semantic Fluency in the Diabetes Heart Study, a type 2 diabetes-enriched familial cohort (n = 893).

Methods

To d

SUBMITTER: Martelle SE 

PROVIDER: S-EPMC4797918 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature