A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.

ABSTRACT: Sleep dysfunction and stress susceptibility are comorbid complex traits that often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multilevel organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J × A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally and cell-type-specific gene co-regulations important for stress and sleep. Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress. The key network regulators of this module are overrepresented with genes imp

SUBMITTER: Jiang P 

PROVIDER: S-EPMC4797932 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature