Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, characterized by recurrent relapses of inflammation that cause mild to severe disability. Exposure to airborne particulate matter (PM) has been associated with acute increases in systemic inflammatory responses and neuroinflammation. In the present study, we hypothesize that exposure to PM<10μm in diameter (PM10) might increase the occurrence of MS-related hospitalizations.

Methods

We obtained daily concentrations of PM10 from 53 monitoring sites covering the study area and we identified 8287 MS-related hospitalization through hospital admission-discharge records of the Lombardy region, Italy, between 2001 and 2009. We used a Poisson regression analysis to inve

SUBMITTER: Angelici L 

PROVIDER: S-EPMC4797990 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature