Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer.

ABSTRACT: Despite the introduction of novel therapies that maximally decrease androgen-receptor (AR) signaling activity, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease. Even though abiraterone and enzalutamide represent breakthroughs in the treatment of mCRPC and have demonstrated significant survival benefits, a significant proportion of patients have primary resistance to these agents and virtually all patients develop secondary resistance. While the mechanisms of resistance to these agents are not fully understood, many hypotheses of AR-dependent and AR-independent mechanisms are emerging, including upregulation of AR and cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17), induction of AR splice variants, AR point mutations, upregulation of glucocorticoid recept

SUBMITTER: Boudadi K 

PROVIDER: S-EPMC4798019 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature