Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait.

ABSTRACT: Determining how genetic variation alters the expression of heritable phenotypes across conditions is important for agriculture, evolution, and medicine. Central to this problem is the concept of genotype-by-environment interaction (or 'GxE'), which occurs when segregating genetic variation causes individuals to show different phenotypic responses to the environment. While many studies have sought to identify individual loci that contribute to GxE, obtaining a deeper understanding of this phenomenon may require defining how sets of loci collectively alter the relationship between genotype, environment, and phenotype. Here, we identify combinations of alleles at seven loci that control how a mutationally induced colony phenotype is expressed across a range of temperatures (21, 30, and 37 °C)

SUBMITTER: Lee JT 

PROVIDER: S-EPMC4798298 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature