Association Between Polymorphism rs678653 in Human Cyclin D1 Gene (CCND1) and Susceptibility to Cancer: A Meta-Analysis.

ABSTRACT:

Background

To assess the association between polymorphism rs678653 in human Cyclin D1 gene (CCND1) and the risk of cancer.

Material/methods

Multiple biomedical databases were systematically searched. Pooled odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated in the appropriate model.

Results

In total, 17 case-control studies from 14 articles were included. When combing all available data, no significant association of rs678653 with cancer risk was observed under different genetic models. Stratification by ethnicity also indicated that rs678653 was not correlated with cancer risk in Taiwanese or Indian populations. When stratified by cancer type, no significant association was found between polymorphism rs678653 and digestive tract cancer, head and

SUBMITTER: Dai X 

PROVIDER: S-EPMC4798325 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature