Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31.

ABSTRACT:

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Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of this study was to explore the potential effects of stem cell-released MVs in proangiogenic therapy. We observed for the first time that MVs were released from adipose-derived stem cells (ASCs) and were able to increase the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Endothelial differentiation medium (EDM) preconditioning of ASCs upregulated the release of MVs and enhanced the angiogenic effect of the released MVs in vitro. RNA an

SUBMITTER: Kang T 

PROVIDER: S-EPMC4798737 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature