History of uterine leiomyoma and risk of endometrial cancer in black women.

ABSTRACT:

Background

Previous studies have found an association between uterine leiomyomata (UL) and uterine malignancies. This relation has not been studied in black women, who are disproportionately affected by UL.

Methods

We investigated prospectively the association between self-reported physician-diagnosed UL and endometrial cancer in the Black Women's Health Study. During 1995-2013, 47,267 participants with intact uteri completed biennial health questionnaires. Reports of endometrial cancer were confirmed by pathology data from medical records and cancer registries. Cox regression was used to derive incidence rate ratios (IRR) and 95% confidence intervals (CI).

Results

There were 300 incident endometrial cancer cases during 689,546 person-years of follow-up. In multivaria

SUBMITTER: Wise LA 

PROVIDER: S-EPMC4798859 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature