Ontology highlight
ABSTRACT:
SUBMITTER: Mo F
PROVIDER: S-EPMC4798883 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature chemical biology 20160201 4
Faithful segregation of chromosomes in mammalian cells requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying cyclin-dependent kinase 1 (CDK1) activation, which triggers mitotic entry, have been extensively studied, the regulatory mechanisms that couple CDK1-cyclin B activity to chromosome stability are not well understood. Here, we identified a signaling axis in which Auro ...[more]