Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.

ABSTRACT:

Rationale

Enhanced activation of the mineralocorticoid receptors (MRs) in cardiovascular tissues increases oxidative stress, maladaptive immune responses, and inflammation with associated functional vascular abnormalities. We previously demonstrated that consumption of a Western diet (WD) for 16 weeks results in aortic stiffening, and that these abnormalities were prevented by systemic MR blockade in female mice. However, the cell-specific role of endothelial cell MR (ECMR) in these maladaptive vascular effects has not been explored.

Objective

We hypothesized that specific deletion of the ECMR would prevent WD-induced increases in endothelial sodium channel activation, reductions in bioavailable nitric oxide, increased vascular remodeling, and associated increases in vascula

SUBMITTER: Jia G 

PROVIDER: S-EPMC4798906 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature