Ixekizumab for the Treatment of Psoriasis: A Review of Phase III Trials.

ABSTRACT:

Introduction

Interleukin-17 inhibitors are the newest class of monoclonal antibodies approved by the US Food and Drug Administration for the treatment of psoriasis. Preclinical and Phase II studies of ixekizumab, a high-affinity anti-IL-17A monoclonal antibody, have proved promising.

Methods

We conducted an extensive literature search using the PubMed database to assess the efficacy and safety profile of ixekizumab. The search included the following key words: "psoriasis" and "IL-17" or "ixekizumab." We also reviewed citations within articles to identify relevant sources.

Results

By week 12, the percentage of patients achieving a 75% improvement from baseline Psoriasis Area and Severity Index (PASI 75) was comparable among the three Phase III trials (UNCOVER-1, 89%; U

SUBMITTER: Farahnik B 

PROVIDER: S-EPMC4799032 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature