Association of ENAM gene single nucleotide polymorphisms with dental caries in Polish children.

ABSTRACT:

Objectives

The objective of this study was to prove the association between dental caries and single nucleotide polymorphisms (SNPs) in the ENAM gene.

Material and methods

The research was carried out in 96 children (48 with caries and 48 counterparts free of this disease), aged 20-42 months, with 11-20 erupted teeth. All children were from four day nurseries located in Poznan. The study included the dental examination to select individuals to the research and oral swab collection for molecular evaluation. Seven selected SNPs markers of the ENAM gene were genotyped, five using TaqMan probe assay (rs2609428, rs7671281, rs36064169, rs3796704, and rs12640848) and two by Sanger sequencing (rs144929717 and rs139228330).

Results

Statistically significant higher prevalence o

SUBMITTER: Gerreth K 

PROVIDER: S-EPMC4799241 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature