Biological factors that place women at risk for HIV: evidence from a large-scale clinical trial in Durban.

ABSTRACT:

Background

It is well documented that the mucosal linings of the female genital tract (FGT) usually provides a robust barrier that protects against sexually acquired infections. However, to the best of our knowledge there are limited South African studies that have investigated the association between damage to the mucosal linings and the acquisition of HIV infections. We hypothesize that in this cohort of women, a higher rate of HIV seroconversions will be observed for women who present with evidence of mucosal damage.

Methods

We undertook a secondary analysis of the Methods for Improving Reproductive Health in Africa (MIRA) trial that assessed the effectiveness of the latex diaphragm and lubricant gel on HIV prevention among women. Participants underwent a physical examina

SUBMITTER: Abbai NS 

PROVIDER: S-EPMC4799526 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature